Cy Burnot wrote:

If I clone my C: drive to another HD of the same or larger size, and
then remove the C: drive and replace it with the clone, should I
expect any glitches when I turn the power back on?

Using Macrium Reflect to make the clone.

If you choose the easy option "Create an image of the partition(s)
required...", you're making a perfect backup copy, not a clone.

You must restore the Macrium Reflect backup copy of your choice to a C
drive.

Use a relatively small SDD for your windows/main drive C. Then make
incremental backup copies, which BTW are also read-only browsable. That
makes for a wonderful system.