Char Jackson wrote on 2/10/2015 2:27 PM:
They're different kinds of threats. With Regedit, you're navigating to a
particular location within the Registry, reviewing the entry that you find
there, and making a decision on whether to leave it alone, change it, or
delete it.

With most Registry 'cleaners', at least the way some seem to use them, you
click to start the program and you click again to make umpteen changes.
There's no review step. There *can* be a review step, but some people choose
to skip it and blindly allow multiple changes. If things break, it can be
pretty hard to find and fix the culprit.

Just for fun, I ran CCleaner and got the following kinds of problems:

Missing Shared DLL
Unused file extension
ActiveX/COM Issue
Application Paths Issue
Installer Reference Issue
Obsolete software key

The ActiveX/COM Issues referred to InProcServer32 and LocalServer32. ???