Windows cannot find 'C:\Documents'.

Hi guys,

I am terribly having a pop up message and lag problem when I turn on my PC.

I'm getting this error message when everything is done loading:
[desktop]

"Windows cannot find "'C:\Documents'. Make sure you typed the name
correctly, and then try again. To search for a file, click the Start button,
and then click Search."

and when I turn off my computer there are several messages that pop ups
before it turns it off. [it has something to do with RUN32.dll if im not
mistaken]

I tried following the suggestions like this one:

"
Go to 'Run' and then key in 'regedit'
After that the Registry Editor windows will be pop out
press alt+F, 'find windows' will be pop up
then key in 'adobe\manager.exe' and press 'Find Next'
just delete the file 'Run' with data "C:\Documents and Settings\Users\ . . .
under the Folder - Windows NT - CurrentVersion - Windows
"

but I can't seem to be finding the
'RUN' file from the registry when its finished searching. or when I click
FIND NEXT, It doesn't show any results...

Please help me, my laptop and my computer is at stake. I got this virus when
I inserted my friends USB into my computer, and then the next time I turned
it on, it started showing. By The Way, my operating system is windows XP.

Thanks in advance.